Primary orbital ganglioneuroma in a 2-year-old healthy boy

Clinical photograph prior to surgery showing proptosis of the left eye.

Coronal unenhanced CT scans demonstrate low attenuation and homogeneous mass.

Axial unenhanced CT scans demonstrate low attenuation and homogeneous mass with slight to moderate patchy homogeneous enhancement.

Sagital view of an orbital T1-weighted magnetic resonance image showing a well-defined, lobulated mass with fibrous septations without invasion of the bone.

Gross photograph of the neoplasm showing a circumscribed lesion with a variegated tan-white surface lacking necrosis.

Hematoxylin–eosin staining showing mature ganglion cells within a neurofibrillary matrix and no neuroblastoma (original magnification 200×).

Immunohistochemical stains showed ganglion cells exhibiting strong cytoplasmic positivity S-100 protein.